Recent Posts

December 17th, 2011

Podcast 139: CPAP for obstructive sleep apnea seems to improve some measures of the metabolic syndrome

A double-blind crossover study in the New England Journal of Medicine shows that 3 months of continuous positive airway pressure (CPAP) in patients with moderate to severe obstructive sleep apnea ameliorates some components of the metabolic syndrome, which is present in about three quarters of such patients.

The authors acknowledge the difficulty of motivating patients to use CPAP consistenly, which could limit its use in routine practice, and they stress the need for counseling to accompany any CPAP prescription.

Links:

Physician’s First Watch coverage (free)

New England Journal of Medicine article (free)

December 9th, 2011

Podcast 138: Why do kids in the U.S. get so many inappropriate broad-spectrum antibiotics?

When kids go for ambulatory care, they get an antibiotic prescribed about 20% of the time. Half of those antibiotics are of the broad-spectrum variety.

What are the factors leading up to this, and what are some resources to turn to for better information on this dangerous situation?

Listen in to  this 27-minute podcast with the first author of a Pediatrics study examining the issue.

Links:

Physician’s First Watch coverage of the Pediatrics paper (free)

Get Smart: Know When Antibiotics Work (free CDC site mentioned by Dr. Hersh)

Get Smart for Healthcare (free CDC site)

Rising Plague by Brad Spellberg (book mentioned by Hersh)

ASM statement on the GAIN Act (legislation mentioned by Hersh)

November 18th, 2011

Podcast 137: Clamping the umbilical cord — what’s the big rush?

A study from Sweden shows that immediate clamping of the cord at birth isn’t such a great idea from the standpoint of the baby’s iron stores.

BMJ‘s editorialist thinks it may be time to change practice in this area.

Listen in — this will be on the test!

Physician’s First Watch coverage

BMJ article

BMJ editorial

November 4th, 2011

Podcast 136: Aspirin lowers colorectal risks in Lynch syndrome — what are the implications for everyone else?

Last week’s Lancet article on the effect of aspirin on risks for colorectal cancer in patients with Lynch syndrome — a group at particularly high risk — may hold implications for preventing sporadic colon cancers.

Our interview with Prof. Sir John Burn, the study’s first author, explores those implications as well speculations on why  we human beings aren’t getting the salicylates we were when our vegetables weren’t so pampered.

Links:

October 28th, 2011

Podcast 135: HPV vaccine effective against anal intraepithelial neoplasia in MSM. Now, how to get it to young men before they’re sexually active?

The quadrivalent HPV vaccine was effective at preventing anal intraepithelial neoplasias in men who have sex with men, it was reported last week.

The larger question is how to get it to young men before they become sexually active.

We interview Dr. Joel Palefsky of UCSF, the first author on a paper in the New England Journal of Medicine that demonstrates the vaccine’s efficacy.

Links:

October 14th, 2011

Podcast 134: How (and why) surveillance in Barrett’s esophagus should change

Barrett’s esophagus no longer carries the promise of esophageal cancer that it seemed to, but it bears watching, especially in the first year after the finding, when most cancers are found.

The first author of this week’s New England Journal of Medicine study tracking the progression of a finding of Barrett’s over a median 5-year period offers some advice on how to proceed.

Links:

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