Articles matching the ‘Vaccination’ Category

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February 21st, 2020

Podcast 253: Is a single-dose HPV vaccination effective?

With human papillomavirus vaccine in short supply around, moving from a three- or two-dose regimen to one dose would immediately double or treble supplies, cut costs, and simplify logistics. A careful study in Cancer by this week’s guest, Ana Rodriguez, and her colleagues adds to the evidence that single-dosing is possible and protective against pre-cancerous cervical lesions. […]


April 4th, 2018

Podcast 220: Mumps outbreaks — blame waning protection, not new viruses or bad vaccines

Mumps outbreaks keep happening, even among vaccinated groups. Why? Our guest, Joseph Lewnard, and his coauthor, Yonstan Grad, probed studies of mumps vaccine efficacy carried out over five decades. They show that the fault, dear clinician, is not in our vaccines or new viral strains, but in ourselves. Our bodies slowly lose their immune response after […]


June 12th, 2015

Podcast 176: HPV Vaccine — How many doses are needed to confer protection?

Running time: 19 minutes We talk with Dr. Cosette Wheeler about a new Lancet Oncology paper that offers follow-up on two major trials of HPV-16/18 vaccines. The analysis adds more data to the suspicion that although three doses of vaccine are optimal, two or even one may offer substantial protection. Wheeler is very cautious on this point, […]


April 14th, 2012

Podcast 151: Most people above age 10 have at least some cross-reactive antibodies to variant influenza

Influenza A (H3N2)v — a novel flu virus that emerged last summer and shows signs of being able to transmit itself from person to person — is our topic this week. The virus carries genes from swine and avian flu viruses, and the few cases found in the U.S. all made complete recovery. We talk with CDC […]


October 28th, 2011

Podcast 135: HPV vaccine effective against anal intraepithelial neoplasia in MSM. Now, how to get it to young men before they’re sexually active?

The quadrivalent HPV vaccine was effective at preventing anal intraepithelial neoplasias in men who have sex with men, it was reported last week. The larger question is how to get it to young men before they become sexually active. We interview Dr. Joel Palefsky of UCSF, the first author on a paper in the New England Journal […]


September 23rd, 2011

Podcast 131: Measuring the effect of the rotavirus vaccine program on kids in the U.S.

Vaccines work, and here’s more evidence. The quadrivalent rotavirus vaccine introduced in 2006 has dramatically lowered hospitalizations for rotavirus-related diarrhea among children under age 5, among other benefits. Its presence has produced a kind of herd immunity whereby even the unvaccinated are reaping benefits. It bears remembering, though, that vaccinees have about a 90% lower […]


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