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August 23rd, 2018

Podcast 224: What’s a “preprint server,” and how might it change how we think about journals?

(4 votes, average: 5.00 out of 5)

Rohan Khera wrote an editorial in The BMJ to accompany his own paper on guidelines for hypertension treatment. In it, he wrote, not about his research, but about the way biomedical articles are published now, and how preprint servers could change that. (In essence, pre-print servers are online repositories of rough drafts of research available for all to see; articles on such servers have not been subjected to peer review.)

Khera’s research article, it should be noted, originally appeared months earlier in draft form on BioRxiv, a biomedical preprint server.

Khera argues that the “official” journals are too slow. He fears their slowness. for instance, can prevent important data from reaching policymakers when it’s most needed — while they are making decisions based on new research languishing in the standard publication process.

Khera’s BMJ commentary

Khera et al.’s preprint on BioRxiv

Khera et al.’s resarch article as published in The BMJ

Conversation with Harlan Krumholz (from 2016): “Rethinking what medical journals do”

August 14th, 2018

Podcast 223: What are the implications of the BP guidelines?

(7 votes, average: 4.43 out of 5)

If adopted, last December’s ACC/AHA guidelines on what pressure levels signal hypertension would label almost two thirds of the U.S. population between ages 45 and 75 as having the condition. The number of people who would be candidates for treatment would almost double — from 8 million to about 15 million.

What are the implications of this for clinicians?

Harlan Krumholz, senior author of an analysis in The BMJ, talks about the problems and the opportunities for collaboration with patients.

BMJ article (free)

July 19th, 2018

Podcast 222: Growing prominence of NPs in primary care

(1 votes, average: 5.00 out of 5)

This time we talk with Dr. Hilary Barnes, first author of a Health Affairs paper: “Rural and Nonrural Primary Care Physician Practices Increasingly Rely on Nurse Practitioners.”

I thought listeners might want to know more about the dramatic change in the way primary care is acquiring, in Barnes’s words, an “increasing interdisciplinary character.”

Health Affairs abstract

April 10th, 2018

Podcast 221: Pertussis makes a comeback — kids have an outsize role

(2 votes, average: 4.00 out of 5)

What’s causing this resurgence, and what’s to be done? Pejman Rohani talks about his Science Translational Medicine study that used “gold standard” historical data to examine possible causes.

He and his colleagues conclude that, as with mumps, slowly waning vaccine protection is at play. However, they identify the “core transmission group” as schoolchildren, who have a greater frequency of contacts. Adults, they find, have “at most a minor role.”

LINKS:

April 4th, 2018

Podcast 220: Mumps outbreaks — blame waning protection, not new viruses or bad vaccines

(2 votes, average: 5.00 out of 5)

Mumps outbreaks keep happening, even among vaccinated groups. Why?

Our guest, Joseph Lewnard, and his coauthor, Yonstan Grad, probed studies of mumps vaccine efficacy carried out over five decades. They show that the fault, dear clinician, is not in our vaccines or new viral strains, but in ourselves. Our bodies slowly lose their immune response after vaccination, and about 25 years after the last vaccine dose, it’s gone.

Listen in.

Links:

Science Translational Medicine study

CDC recommends a third dose of MMR vaccine in an outbreak

March 28th, 2018

Podcast 219: Digital rectal exams shouldn’t be routine in primary care

(2 votes, average: 4.50 out of 5)

There simply isn’t enough evidence to sustain its continued use in asymptomatic men, argues our guest. Dr. Jason Profetto, senior author on an Annals of Family Medicine meta-analysis.

 

Links:

Annals of Family Medicine abstract

Physician’s First Watch coverage

Clinical Conversations

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