July 6th, 2022
Podcast 295: How should clinicians manage severe (but asymptomatic) carotid artery stenosis while awaiting CREST-2’s results?
CREST-2’s results are probably more than a year away. In the meantime, what to do about diagnosed severe (but asymptomatic) carotid stenosis? Recent results suggest that medical management compares favorably with the surgical approach. In this edition, we address the question with a conversation between Dr. Allan Brett, NEJM Journal Watch‘s editor-in-chief, and Dr. Seemant Chaturvedi, […]
February 18th, 2016
Podcast 195: Pioglitazone for secondary prevention?
Pioglitazone, long known to increase insulin sensitivity, has been “mostly relegated to use in unusual conditions such as lipodystrophies” after its drug class, the thiazolidinediones, “fell from grace” in the words of our guest. Dr. Clay Semenkovich has just written an editorial comment on a study in the New England Journal of Medicine. That study […]
November 12th, 2013
Podcast 169: New guidelines on cardiovascular disease prevention
Running time: 11 minutes The American Heart Association/American College of Cardiology have released four sets of guidelines — all aimed at the lowering of risk for atherosclerotic cardiovascular disease. For perspective, we’ve asked Harlan Krumholz, editor-in-chief of NEJM Journal Watch Cardiology and CardioExchange to chat. Links: Risk calculator (free) CardioExchange (free) Circulation homepage New York Times piece by Krumholz on […]
August 15th, 2013
Podcast 165: The Mediterranean diet’s salutary interaction with risk-conferring genes
Running time: 14 minutes. A study in Diabetes Care shows that people at higher genetic risk for diabetes and cardiovascular complications had a relatively lower stroke risk when they adhered to a Mediterranean diet. Dr. Jose Ordovas, the study’s senior author, is our guest for this discussion about the interaction between genes and diet — and […]
March 29th, 2012
Podcast 150: Depression (and antidepressant use) after stroke or TIA
After stroke or transient ischemic attack, depression is more common than among the general population, and the risk for depression extends beyond the early time period after the event. More alarmingly, less than a third of those with persistent depression — defined as depression detected both at 3 and 12 months after the cerebrovascular event — […]
January 13th, 2012
Podcast 141: Clinically apparent atrial fibrillation increases stroke risk; does subclinical afib do the same?
Yes, it apparently does. An international study in the New England Journal of Medicine monitored subclinical atrial fibrillation among some 2600 patients who’d just received an implanted pacemaker or cardioverter-defibrillator. After 3 months of monitoring, about 10% of the group showed subclinical episodes of afib lasting at least 6 minutes. Over an additional 2.5 years of follow-up the […]
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