October 8th, 2011
Podcast 133: Over 50 years later, DES’s adverse effects continue
A cluster of clear-cell adenocarcinomas of the vagina in young women led to the realization some 40 years ago that almost all their mothers had taken diethylstilbestrol during pregnancy — a drug in wide use in the early 1950s. In a follow-up to that drug disaster, researchers (including one of the authors of the original reports […]
July 8th, 2011
Podcast 125: The smoking-cessation drug varenicline poses some difficult tradeoffs.
There is a new meta-analysis from the Canadian Medical Association Journal that finds increased risks among smokers trying to quit and taking varenicline (Chantix). Among smokers with stable cardiovascular disease, the number needed to treat to cause an adverse cardiovascular event is about 30, yet the number needed to treat to achieve smoking cessation is 10. […]
May 14th, 2011
Podcast 121: NSAIDs Unsafe at Any Dose after MI
Guidelines warn about using NSAIDs after myocardial infarction, and a 10-year look-back study from Denmark shows that the warning should be even louder. Whereas current AHA guidelines advise using NSAIDs after MI for the briefest possible time, the Danish study, published last week in Circulation, finds that the risks for death and reinfarction begin within […]
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