September 9th, 2014
Podcast 174: PARADIGM and Heart Failure
The PARADIGM-HF trial of LCZ696 — a novel compound that both blocks the renin-angiotensin system with an ARB component and blocks neprilysin’s degradation of natriuretic peptides — increased survival in heart failure by some 20% relative to enalapril. It seems to be a big deal, and the trial’s two principal authors have agreed to talk […]
May 2nd, 2012
Podcast 154: Treating heart failure’s hypercoagulable state — warfarin or aspirin?
Heart failure brings problems associated with hypercoagulation, such as stroke and sudden death. An international study followed some 2300 patients with heart failure (ejection fractions of 35% or less) and in stable sinus rhythm for a mean of 3.5 years, randomizing them to treatment with either warfarin or aspirin. The two treatment groups showed about the same […]
May 7th, 2010
Podcast 86: Prompt follow-up after discharge for heart failure reduces early-readmission rates.
Why wouldn’t you want your hospital to lower its rate of early readmissions for heart failure by 15%? We talk with Dr. Adrian Hernandez about his examination of Medicare data from over 200 hospitals, how the hospitals vary widely in the rates at which their patients are followed up within a week of discharge for […]
February 28th, 2009
Podcast 32: Reprise of a June 2008 interview with Larry Allen from Duke, in which he talks about patients’ estimates of their life expectancy, compared with what disease models predict.
We’ve run into a scheduling problem with the person we wanted to talk with. We’ll try again next week, because his views are intriguing and I’m guessing you’d rather have intriguing than ho-hum. However, so that you won’t have wasted your time downloading the podcast, I’ve reprised an interview from last June, when few of […]
June 20th, 2008
Podcast 4: News and interview with Dr. Larry Allen, Clinical Instructor in Cardiology, Duke
Larry Allen talks with us about patients’ estimates of their life expectancy, compared with what disease models predict. Antiepileptic drugs http://firstwatch.jwatch.org/cgi/content/full/2008/619/1 Antipsychotic drug http://general-medicine.jwatch.org/cgi/content/full/2007/315/5 Inhalers http://pediatrics.jwatch.org/cgi/content/full/2008/618/1 Induced labor http://womens-health.jwatch.org/cgi/content/full/2008/619/1 Rate vs. rhythm http://cardiology.jwatch.org/cgi/content/full/2008/618/2 Dr. Allen interview http://depts.washington.edu/shfm/ http://jama.ama-assn.org/cgi/content/abstract/299/21/2533 http://cardiology.jwatch.org/cgi/content/full/2008/618/5 http://cardiology.jwatch.org/cgi/content/full/2008/618/5 http://firstwatch.jwatch.org/cgi/content/full/2008/604/1
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