May 14th, 2011
Podcast 121: NSAIDs Unsafe at Any Dose after MI
Guidelines warn about using NSAIDs after myocardial infarction, and a 10-year look-back study from Denmark shows that the warning should be even louder. Whereas current AHA guidelines advise using NSAIDs after MI for the briefest possible time, the Danish study, published last week in Circulation, finds that the risks for death and reinfarction begin within […]
May 6th, 2011
Podcast 120: Pass the salt!
European researchers say they’ve got the data to show that restricting salt in the general population is a bad mistake. By implication, the U.S. dietary salt guidelines are plainly wrong. How did they do this? They followed 3700 subjects for roughly 8 years, having first measured their 24-hour urinary sodium excretion. Their data show that lower […]
April 22nd, 2011
Podcast 119: Calcium supplements and risk
Most clinicians, when asked, say they will routinely recommend calcium supplements for their postmenopausal patients. A meta-analysis from BMJ shows that this well-intentioned advice seems to lead to a moderate increase in cardiovascular risk in these women. We talk with Prof. Ian Reid, whose re-analysis of Women’s Health Initiative data confirms earlier work he’d done. Listen in. […]
April 8th, 2011
Podcast 118: Opioid prescribing patterns and accidental overdoses
Two authors of a JAMA study published earlier this week discuss how prescribing patterns for opioids figured in the rates of unintentional overdose. The work was done using data from Veterans Administration records. Briefly, they found that the risk for overdose was directly related to the maximal dose prescribed, however, patients who received only “as […]
April 1st, 2011
Podcast 117: Atorvastatin and new-onset diabetes
Statins, according to a 2010 meta-analysis in Lancet, are associated with a slightly increased risk for new-onset type 2 diabetes. One, atorvastatin (marketed as Lipitor), was underrepresented in that analysis. Researchers, along with the manufacturer, decided to have a look at data from three trials to see whether atorvastatin also conferred that risk. And, indeed […]
March 25th, 2011
Podcast 116: What do more sensitive troponin measurements mean for diagnosing ACS?
Troponin I levels can now be measured much more accurately and assays have a greater sensitivity. In Edinburgh, the diagnostic level for acute coronary syndrome was lowered from 0.20 ng/mL to 0.05. As a result, when patients presented with suspected ACS they were more likely to be diagnosed — and a year later were more […]
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