September 9th, 2014
Podcast 174: PARADIGM and Heart Failure
The PARADIGM-HF trial of LCZ696 — a novel compound that both blocks the renin-angiotensin system with an ARB component and blocks neprilysin’s degradation of natriuretic peptides — increased survival in heart failure by some 20% relative to enalapril. It seems to be a big deal, and the trial’s two principal authors have agreed to talk […]
May 2nd, 2012
Podcast 154: Treating heart failure’s hypercoagulable state — warfarin or aspirin?
Heart failure brings problems associated with hypercoagulation, such as stroke and sudden death. An international study followed some 2300 patients with heart failure (ejection fractions of 35% or less) and in stable sinus rhythm for a mean of 3.5 years, randomizing them to treatment with either warfarin or aspirin. The two treatment groups showed about the same […]
November 19th, 2010
Podcast 109: An overview of the American Heart Association meeting, with cardiologist Harlan Krumholz
We’ve got Dr. Harlan Krumholz, editor of Journal Watch Cardiology and CardioExchange, to guide us through a week’s worth of the top research presented at the American Heart Association in Chicago. Interview-related links (in the order we discuss them in the interview): CardioExchange (worth checking out — it’s an experiment in the clinical use of social media) […]
May 7th, 2010
Podcast 86: Prompt follow-up after discharge for heart failure reduces early-readmission rates.
Why wouldn’t you want your hospital to lower its rate of early readmissions for heart failure by 15%? We talk with Dr. Adrian Hernandez about his examination of Medicare data from over 200 hospitals, how the hospitals vary widely in the rates at which their patients are followed up within a week of discharge for […]
March 27th, 2010
Podcast 80: Bisphosphonates and atypical hip fractures — how large is the risk?
We talk with three of the academic authors of a New England Journal of Medicine study that pooled data from a few studies in an attempt to examine the possible link between use of bisphosphonates and femoral-shaft fractures. Interview-related links: Physician’s First Watch coverage NEJM paper NEJM editorial FDA statement News-related links: Aspirin ineffective in preventing miscarriage BNP-guided […]
December 5th, 2009
Podcast 68: Change your approach to pharyngitis in adolescents and young adults.
Dr. Robert Centor of the University of Alabama at Birmingham believes that the paradigm for treating pharyngitis in adolescents and young adults must change. Listen to our conversation and hear why. Here are this week’s links: Interview: Commentary Urges ‘Expanding the Diagnostic Paradigm of Pharyngitis’ in Young People Robert Centor’s blog — “Medrants” News stories: Chronic Pain Linked […]
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