Clinical Conversations

May 2nd, 2010

Podcast 85: B vitamins lower homocysteine levels, so why don’t they retard the progression of diabetic nephropathy?

A surprise finding: homocysteine is supposed to be a factor in vascular inflammation, but lowering hyperhomocysteinemia in patients with diabetic nephropathy actually accelerated the decline of  their GFRs. What gives? We have a conversation with Dr. J. David Spence, whose results were just published in JAMA. Interview-related link: JAMA paper on the effect of B vitamins on diabetic […]

---

July 10th, 2009

Podcast 49: Three RASS Study researchers discuss their findings on the lack of benefit of renin-angiotensin blockade in the primary prevention of diabetic nephropathy in Type 1 diabetes.

We talk with Drs. Michael Mauer, Ronald Klein, and Bernard Zinman about their paper in the July 2 New England Journal of Medicine reporting on the RASS study (Renin-Angiotensin System Study). They found that blockade of the renin-angiotensin system was not effective in the primary prevention of diabetic nephropathy in Type 1 diabetes. This week’s […]

---