June 27th, 2022
Podcast 293: HER2-“low” breast cancer and its reponse to an antibody-drug conjugate
Patients with metastatic breast cancer whose tumors express low levels of HER2 are generally classified and treated as having HER2-negative disease. However, Dr. Shanu Modi of the Memorial Sloan Kettering Cancer Center and a group of international collaborators explored the use of a monoclonal antibody–drug conjugate (trastuzumab–deruxtecan) in patients with disease they classify as HER2-“low.” Compared […]
February 21st, 2018
Podcast 216: What role for MRI in breast cancer screening?
A recent paper in JAMA Internal Medicine sought to examine what happens after breast cancer screening with magnetic resonance imaging. It reported that core and surgical biopsy rates doubled, compared with mammography, in women with a personal history of breast cancer; they rose fivefold among women with no personal breast cancer histories. Dr. Diana Buist, the […]
March 25th, 2016
Podcast 200: Sorting out the results of breast biopsy
Most of the time, pathologists agree with each other about breast biopsy results — especially when the biopsy is negative or indicates invasive cancer. However, the biopsies that fall between those two extremes — that is, atypia and ductal carcinoma in situ — make for tough conversations with patients. This week’s guest, Alexander Borowsky, has written […]
November 10th, 2012
Podcast 159: Making the Clinical Diagnosis, But Blowing the Patient’s Treatment Preference
Running time: 20 min. In some diseases there are two diagnoses to make: the clinical diagnosis and the diagnosis of what the patient’s treatment preference is. The first is hard enough to make, and the widening choice of treatment choices complicates the second. Welcome to the task of “preference diagnosis,” which can lead to disappointment and worse […]
February 12th, 2010
Podcast 74: How two SSRIs apparently interfere with tamoxifen therapy.
We talk with Dr. Catherine Kelly about her study in BMJ showing serious interference of some SSRIs with tamoxifen therapy in breast cancer. The study was conducted using Canadian provincial databases. Reach us at 1-617-440-4374 or by email to jelia@jwatch.org. Interview article: BMJ study Physician’s First Watch coverage Medical news links: Back pain guidelines Inflammatory bowel disease and venous […]
January 15th, 2010
Podcast 70: Considering the USPSTF breast-screening guidelines with your patients
This is the podcast for January 15, 2010. We have an interview on the impact of the USPSTF guidelines with two clinicians who study the best ways to communicate clearly with patients. I think you’ll like it. You can reach me at jelia@jwatch.org or by calling 617-440-4374. If you like this podcast, there are many others in […]
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