Clinical Conversations

October 10th, 2017

Podcast 214: Drug-drug interactions and bleeding risks with NOACs

The non-vitamin-K oral anticoagulants (known familiarly as NOACs or DOACs) share metabolic pathways with other drugs, which can potentiate NOACs’ anticoagulant actions dangerously. Dr. Shang-Hung Chang and his group studied Taiwan’s national health insurance database, which records data on virtually all that nation’s citizens, to measure the actual risks of some of these drug – […]

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October 8th, 2011

Podcast 133: Over 50 years later, DES’s adverse effects continue

A cluster of clear-cell adenocarcinomas of the vagina in young women led to the realization some 40 years ago that almost all their mothers had taken diethylstilbestrol during pregnancy — a drug in wide use in the early 1950s. In a follow-up to that drug disaster, researchers (including one of the authors of the original reports […]

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