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Posts Tagged ‘FDA’

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May 19th, 2011

Podcast 122: Most newer antiepileptics apparently safer in early pregnancy — but not all.

A paper from Denmark looks at five newer-generation antiepileptics and finds no strong birth-defects signal associated with their use in the first trimester. However, as the senior author points out in a statement to Clinical Conversations, one of the drugs — topiramate — has only recently been cited by the FDA as carrying a […]


September 26th, 2010

Podcast 102: Short compression stockings would seem to have no further role clinically.

Prof. Martin Dennis chats with us about his latest trial, comparing the utility of thigh- versus below-knee-length stockings for patients immobilized after stroke. The latest results show the superiority of thigh-length stockings, but at the further risk of skin breaks in these vulnerable patients. Taken together with the results of his earlier work, at […]


August 20th, 2010

Podcast 98: Leafy green vegetables apparently lower one’s risks for type 2 diabetes

Our interview this week is with a research nutritionist whose BMJ meta-analysis found a 14% reduction in risk for type 2 diabetes among those with the highest intake (versus those with the lowest) of leafy green vegetables. It’s a meta-analysis, and not a randomized controlled trial, and it’s interesting. Listen in. We’re off next […]


July 30th, 2010

Podcast 96: Survivors of childhood cancer face manageable reproductive risks.

What becomes of children who survive cancer treatment and enter their reproductive years? Would their attempts to have children end in a higher-than-normal rate of stillbirths and miscarriages? Apparently not. It turns out the major concern is with women who’ve undergone pelvic irradiation before menarche. That treatment seems to hobble uterine development, but not […]


May 16th, 2010

Podcast 87: After this week’s news, we reprise an interview from last December on pharyngitis in adolescents and young adults.

Dr. Robert Centor of the University of Alabama at Birmingham believes that the paradigm for treating pharyngitis in adolescents and young adults must change. Listen to our conversation and hear why. Here are this week’s links: Interview-related links: Commentary Urges ‘Expanding the Diagnostic Paradigm of Pharyngitis’ in Young People Robert Centor’s blog — “Medrants” […]


February 27th, 2010

Podcast 76: On saying “No” to patients’ requests.

A conversation with the authors of an Archives of Internal Medicine study that examines the best tactics for saying “No” to inappropriate requests. Contact me at 1-617-440-4374 or at jelia@jwatch.org. Interview-related links: Archives of Internal Medicine abstract Atul Gawande’s New Yorker article News-related links: The rosiglitazone (Avandia) controversy Advisory on thiazolidinediones Physicians’ work hours 13-valent […]


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