Articles matching the ‘Uncategorized’ Category

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August 21st, 2015

Podcast 183: An Obesity ‘Switch’ in the Genome Described

There’s a kind of “wall switch” in the human genome that’s been newly described. It seems to be able to turn on and off genes controlling the efficiency with which we burn fat. The study describing the finding in the New England Journal of Medicine reads like a genetic research tour-de-force, showing how the whole circuit […]


August 16th, 2015

Podcast 182: Dietary fat studies meta-analyzed — trans fat still a bad bet

The BMJ’s meta-analysis of several large cohorts finds no association of saturated fat with all-cause and cardiovascular mortality or total coronary disease. Trans fat, on the other hand, increased risk in all those categories. The first author on the paper, Dr. Russell de Sousza, isn’t ready to give a free pass to saturated fat, though. […]


July 11th, 2015

Podcast 179: Pradaxa (dabigatran) reversal near?

Running time: 20 minutes The anticoagulant dabigatran, marketed in the U.S. as Pradaxa, has always had the problem that, although it’s more convenient to use, there’s no sure way to stop its effect if the patient has a major bleed. Now, a monoclonal antibody fragment called idarucizumab (pronounced i-DARE-you-scis-ooh-mab) shows promise as a reversal agent. In […]


July 4th, 2015

Podcast 178: Why Should Clinicians’ Complicity in CIA Torture Matter to You?

Dr. Scott Allen of Physicians for Human Rights talks about the lessons evident in the complicity of clinicians — physicians, PAs, and psychologists at the very least — in the torture of prisoners. His group published an analysis under the title “Doing Harm: Health professionals’ central role in the CIA torture program,” and that’s the […]


June 12th, 2015

Podcast 176: HPV Vaccine — How many doses are needed to confer protection?

Running time: 19 minutes We talk with Dr. Cosette Wheeler about a new Lancet Oncology paper that offers follow-up on two major trials of HPV-16/18 vaccines. The analysis adds more data to the suspicion that although three doses of vaccine are optimal, two or even one may offer substantial protection. Wheeler is very cautious on this […]


June 3rd, 2015

Podcast 175: “Understanding Value-Based Healthcare” — A Discussion with the Authors of an Important New Book

Running time: 26 minutes “Understanding Value-Based Healthcare,” published in April by McGraw-Hill is today’s focus. Drs. Christopher Moriates, of the University of California, San Francisco; Vineet Arora, of the University of Chicago; and Neel Shah of Harvard Medical — the book’s authors — discuss its straightforward approach to valuing patient outcomes foremost. The discussion ranges over their […]


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